2,6-Difluoro-4-methoxybenzonitrile(CAS: 123843-66-3)

2,6-Difluoro-4-methoxybenzonitrile is a colorless to light yellow liquid with a molecular weight of 210.06 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. Chemically, it is relatively stable but reactive towards bases. It decomposes at high temperatures and reacts with reducing agents.

2,6-Difluoro-4-methoxybenzonitrile is typically synthesized via a nucleophilic aromatic substitution reaction using fluoroform and methoxybenzoyl chloride. The reaction is catalyzed by a Lewis acid such as aluminum chloride, providing good yield and selectivity. The process requires careful control of reaction conditions to achieve high purity.

2,6-Difluoro-4-methoxybenzonitrile is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those targeting metabolic and cardiovascular diseases. It is also utilized in the production of sensors and semiconductors due to its unique electronic properties.

When handling 2,6-Difluoro-4-methoxybenzonitrile, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.