2-Chloro-N-(hydroxymethyl)acetamide(CAS: 2832-19-1)

2-Chloro-N-(hydroxymethyl)acetamide (CAS: 2832-19-1) is a white crystalline solid with a molecular weight of approximately 123.57 g/mol. It has a pKa of approximately 14 and is slightly soluble in water. It reacts readily with bases and shows basic properties. The compound is stable under normal storage conditions but should be kept away from strong acids and oxidizers.

2-Chloro-N-(hydroxymethyl)acetamide (CAS: 2832-19-1) is typically synthesized by the reaction of chloroacetic acid with methylamine or by the chlorination of N-(hydroxymethyl)acetamide. The reaction proceeds with good selectivity and yields can reach up to 90%. Catalysts such as sodium carbonate or potassium carbonate are often used to enhance the reaction efficiency.

2-Chloro-N-(hydroxymethyl)acetamide (CAS: 2832-19-1) is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and in polymer chemistry for the modification of polymers. It also finds applications in the production of sensors and as a precursor in semiconductor manufacturing.

When handling 2-Chloro-N-(hydroxymethyl)acetamide (CAS: 2832-19-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area away from heat and oxidizers. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. A safety data sheet (SDS) should be consulted for detailed handling and emergency procedures.