Fosaprepitant(CAS: 172673-20-0)

Fosaprepitant (CAS: 172673-20-0) is a white to off-white crystalline powder with a molecular weight of approximately 413.53 g/mol. It has poor water solubility but is soluble in organic solvents like ethanol. Chemically, it is stable under normal storage conditions but may degrade under strong acidic or basic conditions. It is a prodrug that is converted to aprepitant, an antagonist of the chemokine receptor 1 (CKR-1), in the body.

Fosaprepitant is synthesized through a multi-step process involving the use of Grignard reagents and Suzuki coupling reactions. The key steps include the formation of ester intermediates and the reduction of the ester to the corresponding alcohol. The final step involves the conversion to the prodrug form. The synthesis typically achieves high yields and high selectivity, making it suitable for pharmaceutical production.

Fosaprepitant (CAS: 172673-20-0) is primarily used in the pharmaceutical industry. It is an important drug compound used in the treatment of nausea and vomiting associated with chemotherapy. While not directly used in industries like polymers or semiconductors, the chemokine receptor 1 (CKR-1) antagonism it provides is of interest in research for its potential in other therapeutic areas.

When handling Fosaprepitant (CAS: 172673-20-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves and protective eyewear. Storage should be in a cool, dry place away from direct sunlight. Fume hoods should be used during handling to minimize inhalation risks. In case of spill, immediately clean up with appropriate absorbents and dispose of materials according to the Material Safety Data Sheet (MSDS/SDS). Always consult the SDS for detailed safety information.