Ethyl 6-chloropyridazine-4-carboxylate(CAS: 612834-90-9)

Ethyl 6-chloropyridazine-4-carboxylate is a white crystalline solid with a molecular weight of approximately 229.6 g/mol. It has a melting point of 135-137°C and is slightly soluble in water. This compound is moderately reactive, showing some tendency towards hydrolysis. It is used in organic synthesis and as a reagent in various chemical processes.

Ethyl 6-chloropyridazine-4-carboxylate is commonly synthesized by reacting 4-chloropyridazine with acetyl chloride in the presence of an acid catalyst, such as phosphoric acid. This reaction is carried out at room temperature, and the product is purified by recrystallization from a suitable solvent. The yield is typically around 75-80%, with good selectivity and reactivity.

Ethyl 6-chloropyridazine-4-carboxylate is used in the pharmaceutical industry for the synthesis of certain drugs and intermediates. It also finds applications in the polymer industry for producing specific polymer additives and in the field of sensors for detecting aromatic compounds. Additionally, it has potential use in the semiconductor industry for specific chemical processes.

When handling Ethyl 6-chloropyridazine-4-carboxylate, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated environment or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Emergency eyewash and shower facilities should be readily available. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information.