Methyl 5-formyl-3-thiophenecarboxylate(CAS: 67808-66-6)

Methyl 5-formyl-3-thiophenecarboxylate is a crystalline solid with a molecular weight of approximately 222.23 g/mol. It has a solubility of about 1.4 g/100 mL in water and is somewhat soluble in common organic solvents like ethanol and acetone. Chemically, it reacts readily with nucleophiles due to the presence of the formyl group. It displays Lewis acidity and can form complexes with various anions.

Methyl 5-formyl-3-thiophenecarboxylate can be synthesized through the reaction of thiophene-3-carboxylic acid and methanol in the presence of a strong acid catalyst like sulfuric acid. The reaction involves esterification, where the carboxylic acid group reacts with methanol to form the methyl ester derivative. The yield of the product is typically around 85%, and the process is carried out under heating conditions to enhance the reaction rate.

Methyl 5-formyl-3-thiophenecarboxylate is utilized in various industries, including pharmaceuticals, where it serves as a precursor to medicinals. It is also used in the production of polymers for advanced materials, as a starting material for chemical sensors, and in the synthesis of semiconductor materials due to its unique chemical properties.

When handling Methyl 5-formyl-3-thiophenecarboxylate, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure the use of a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using absorbent paper and dispose of it properly. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.