[(2S)-4-Benzyl-2-piperazinyl]methanol(CAS: 149715-45-7)

[(2S)-4-Benzyl-2-piperazinyl]methanol (CAS 149715-45-7) is a crystalline solid with a molecular weight of approximately 251.34 g/mol. It has a pKa of around 8.5, indicating basic properties. The compound is slightly soluble in water but more soluble in organic solvents like methanol and ethanol. It is a chiral molecule, and its reactivity is influenced by the presence of the benzyl and piperazine groups, making it useful in various synthetic transformations.

[(2S)-4-Benzyl-2-piperazinyl]methanol can be synthesized via a multi-step process starting from benzylamine and piperazine. The key steps involve the formation of a piperazine derivative, followed by coupling with benzylamine to form the final product. Catalytic hydrogenation is often used to achieve the desired stereoisomer. The overall yield is typically around 70-80%, with high selectivity for the (2S) isomer.

[(2S)-4-Benzyl-2-piperazinyl]methanol (CAS 149715-45-7) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It also finds applications in the polymer industry as a modifier and in sensor technology due to its chemical reactivity. Additionally, its use in semiconductor manufacturing for specific chemical processes is growing.

When handling [(2S)-4-Benzyl-2-piperazinyl]methanol (CAS 149715-45-7), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately with appropriate absorbents, and proper handling and disposal procedures should be followed as per the Material Safety Data Sheet (MSDS/SDS).