Isopropyl trifluoroacetate(CAS: 400-38-4)

Isopropyl trifluoroacetate (CAS: 400-38-4) is a colorless liquid with a molecular weight of approximately 142.13 g/mol. It has a high boiling point of around 81.5°C and low solubility in water. This compound exhibits moderate reactivity, particularly with bases, forming trifluoroacetamide and isopropyl alcohol. It is used in various applications requiring its stability and specific functional groups.

Isopropyl trifluoroacetate (CAS: 400-38-4) is usually synthesized via a nucleophilic substitution reaction between trifluoroacetyl chloride and isopropanol. Commonly, triethylamine is used as a base, and the reaction is carried out under anhydrous conditions to achieve a yield of about 75-85%. The reaction is known for its high selectivity and can be performed under mild conditions without the need for additional catalysts.

Isopropyl trifluoroacetate (CAS: 400-38-4) is primarily utilized in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various drugs and is also used in the formulation of certain polymer coatings and adhesives. Additionally, it is employed in analytical chemistry for derivatization reactions and as a reagent in organic synthesis.

When handling Isopropyl trifluoroacetate (CAS: 400-38-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully, and the material safety data sheet (MSDS) should be referenced for detailed spill procedures. Exposures can lead to irritation and should be avoided. Always ensure proper storage in a cool, dry, and well-ventilated environment away from incompatible materials.