4-Butylbenzoyl chloride(CAS: 28788-62-7)

4-Butylbenzoyl chloride is a colorless to light yellow liquid with a pungent, aromatic odor. It has a molecular weight of approximately 213.26 g/mol and a boiling point of 121-122°C. The compound is soluble in water (25°C: 0.8 g/100 mL) and readily soluble in organic solvents like ethanol, acetonitrile, and toluene. It is reactive and prone to hydrolysis to form 4-Butylbenzoic acid.

4-Butylbenzoyl chloride is synthesized by treating 4-Butylbenzoic acid with thionyl chloride in the presence of a catalyst such as aluminum chloride. The reaction proceeds at room temperature, yielding a crude product that is typically purified by recrystallization or distillation. The overall yield of the reaction is generally around 85-90%.

4-Butylbenzoyl chloride is used in the pharmaceutical industry as a precursor for the synthesis of drugs and intermediates. It is also utilized in the polymer industry for the modification of polymers and in the production of certain types of plastics. Additionally, this compound is employed in the semiconductor industry for the development of photoresists and in the production of sensors.

Handling 4-Butylbenzoyl chloride requires appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood due to its volatility. Spills should be cleaned up with caution using appropriate absorbents and the area should be well-ventilated. Safety data sheets (SDS) should be consulted for detailed emergency response procedures and storage conditions. This compound is reactive and can hydrolyze, so it should be stored in a cool, dry place, away from heat sources and incompatible materials.