5-bromo-7-fluoro-1H-indole(CAS: 883500-73-0)

5-Bromo-7-fluoro-1H-indole has a crystalline form at room temperature. Its molecular weight is approximately 224.03 g/mol. This compound is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It is relatively stable under normal conditions but can be sensitive to strong oxidizing agents.

5-Bromo-7-fluoro-1H-indole can be synthesized via a multistep process involving bromination and fluorination of 1H-indole. Commonly, the bromination is carried out using bromine in the presence of a Lewis acid catalyst like aluminum bromide. The fluorination step typically utilizes hydrogen fluoride or trifluoroacetic anhydride. The overall yield and selectivity depend on the specific reaction conditions and catalysts used.

5-Bromo-7-fluoro-1H-indole is primarily used in the pharmaceutical industry as a precursor for the synthesis of various bioactive compounds. It also finds applications in the polymer industry for the development of novel materials, and in sensors and semiconductors for specific electronic and optical properties.

When handling 5-bromo-7-fluoro-1H-indole, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions. Storage should be in a cool, dry place, away from direct sunlight and heat sources.