Methyl 2-fluoro-3-oxopentanoate(CAS: 180287-02-9)

Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) is a colorless liquid with a molecular weight of approximately 131.06 g/mol. It has a high boiling point around 210°C and is moderately soluble in water. It is reactive towards nucleophiles and can undergo hydrolysis under basic conditions. This compound is stable under normal conditions but should be stored in a cool, dry place away from moisture and strong bases.

Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) is typically synthesized through a condensation reaction between a fluoro carboxylic acid and an alcohol using a coupling agent like dicyclohexylcarbodiimide (DCC). The reaction is usually conducted in an inert solvent like dichloromethane and requires the presence of a catalytic amount of 4-dimethylaminopyridine (DMAP) to enhance the reaction yield. The final product can be isolated by filtration and recrystallization.

Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the manufacturing of polymers and in the development of sensors and semiconductors due to its unique chemical properties. Its versatility makes it a valuable compound in multiple sectors.

When handling Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or in a fume hood to avoid inhalation. Spills should be handled with caution using appropriate absorbents, and the area should be cleaned thoroughly. Always consult the safety data sheet (SDS) for detailed handling and storage guidelines.