1,5-Di-O-phosphono-D-ribofuranose(CAS: 14689-84-0)

1,5-Di-O-phosphono-D-ribofuranose is a colorless crystalline solid with a molecular weight of approximately 252.09 g/mol. It is poorly soluble in water but soluble in organic solvents. This compound is highly reactive, particularly with nucleophiles, and can form ester and phosphodiester linkages under specific conditions.

1,5-Di-O-phosphono-D-ribofuranose is typically synthesized through the phosphorolysis of D-ribofuranose with phosphorus oxychloride or phosphorus pentoxide. The reaction involves a nucleophilic substitution at the 1 and 5 positions, yielding the desired compound with high selectivity and good yield.

1,5-Di-O-phosphono-D-ribofuranose finds applications in pharmaceuticals, particularly in the synthesis of nucleoside analogs for antiviral and anticancer drugs. It is also used in the development of sensors and in the synthesis of certain polymer materials.

When handling 1,5-Di-O-phosphono-D-ribofuranose, safety goggles, gloves, and a lab coat are essential. Reactivity with water and air requires the use of a fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to lab regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.