5-bromo-1H-indole-2-carboxylic acid(CAS: 7254-19-5)

5-bromo-1H-indole-2-carboxylic acid is a white crystalline solid with a molecular weight of 254.05 g/mol. It is slightly soluble in water and more soluble in polar organic solvents. The compound is reactive, particularly in nucleophilic substitution reactions due to the presence of the bromo group and carboxylic acid functionality.

5-bromo-1H-indole-2-carboxylic acid is typically synthesized via bromination of indole-2-carboxylic acid using N-bromosuccinimide (NBS) in the presence of a photoinitiator. The reaction is carried out under UV light, providing high selectivity and good yield.

5-bromo-1H-indole-2-carboxylic acid finds applications in pharmaceuticals, particularly in the synthesis of bioactive compounds and intermediates. It is also used in the development of sensors and semiconductors due to its unique chemical properties.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 5-bromo-1H-indole-2-carboxylic acid. Reactants and products should be handled in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbent materials, and disposal should follow local and regulatory guidelines. Always consult the Safety Data Sheet (SDS) for detailed safety information.