1-(4-Bromophenyl)-2,2,2-trifluoroethanone(CAS: 16184-89-7)

1-(4-Bromophenyl)-2,2,2-trifluoroethanone (CAS: 16184-89-7) is a white or off-white crystalline solid. It has a molecular weight of approximately 319.01 g/mol. This compound is poorly soluble in water but miscible with organic solvents such as ethanol and acetone. It is highly reactive due to the presence of the bromine and trifluoromethyl groups, making it prone to nucleophilic substitution and electrophilic reactions.

1-(4-Bromophenyl)-2,2,2-trifluoroethanone is typically synthesized by the condensation of 4-bromophenol with trifluoroacetic anhydride. This process is often catalyzed by a Lewis acid such as aluminum trichloride. The reaction proceeds via nucleophilic aromatic substitution and acyloin condensation, yielding high yields and good selectivity. Careful control of reaction conditions is essential to achieve the desired product.

1-(4-Bromophenyl)-2,2,2-trifluoroethanone (CAS: 16184-89-7) is used primarily in the pharmaceutical and fine chemical industries for the synthesis of complex organic molecules. It also has applications in the polymer and sensor industries where its unique chemical properties can be utilized.

When handling 1-(4-Bromophenyl)-2,2,2-trifluoroethanone (CAS: 16184-89-7), it is important to wear personal protective equipment (PPE) such as gloves, protective goggles, and lab coats. Work should be conducted in a well-ventilated fume hood. Spills should be carefully managed using absorbent materials and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage precautions.