(E)-3-[2-(Pyridin-2-YL)ethenyl]-1-(tetrahydro-2H-pyran-2-YL)-1H-indazol-6-amine(CAS: 886230-76-8)

(E)-3-[2-(Pyridin-2-YL)ethenyl]-1-(tetrahydro-2H-pyran-2-YL)-1H-indazol-6-amine (CAS: 886230-76-8) is a crystalline solid with a molecular weight of approximately 414.41 g/mol. It has a low solubility in water but is soluble in organic solvents such as DMSO and DMF. This compound exhibits good stability in air and is susceptible to hydrolysis under acidic conditions. It is known for its reactivity in organic synthesis, particularly in nucleophilic substitution reactions.

(E)-3-[2-(Pyridin-2-YL)ethenyl]-1-(tetrahydro-2H-pyran-2-YL)-1H-indazol-6-amine (CAS: 886230-76-8) is synthesized by the cross-coupling reaction of 3-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine with 2-(pyridyl)ethyl vinyl bromide using a palladium catalyst. The reaction is performed in the presence of a base such as cesium carbonate, and the product is isolated by recrystallization from a suitable solvent.

(E)-3-[2-(Pyridin-2-YL)ethenyl]-1-(tetrahydro-2H-pyran-2-YL)-1H-indazol-6-amine (CAS: 886230-76-8) is primarily used in the pharmaceutical industry for its potential as a drug candidate. It also finds applications in the development of sensors and as a building block in organic synthesis for the production of complex molecules.

When handling (E)-3-[2-(Pyridin-2-YL)ethenyl]-1-(tetrahydro-2H-pyran-2-YL)-1H-indazol-6-amine (CAS: 886230-76-8), it is essential to wear appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood. Spills should be managed by the use of absorbent materials and the area should be cleaned with an appropriate solvent. A Safety Data Sheet (SDS) should be consulted for detailed safety information.