6-Methyl-1H-pyrrolo[3,2-c]pyridine(CAS: 183586-34-7)

6-Methyl-1H-pyrrolo[3,2-c]pyridine is a crystalline solid with a molecular weight of approximately 153.17 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. The compound shows moderate reactivity towards nucleophiles and electrophiles, making it useful for various chemical transformations. It is characterized by its aromatic nature and the presence of a methyl group substituent.

6-Methyl-1H-pyrrolo[3,2-c]pyridine can be synthesized through the condensation of pyridine and acetylacetone in the presence of a Lewis acid catalyst, such as aluminum trichloride. The reaction proceeds under mild conditions, and the product can be isolated by recrystallization. The yield is generally good, around 70-80%, and the selectivity is high, producing the desired 6-methylpyrrolo[3,2-c]pyridine with high purity.

6-Methyl-1H-pyrrolo[3,2-c]pyridine is used in the pharmaceutical industry for the synthesis of certain drug candidates due to its biological activity. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, the compound finds applications in the sensor and semiconductor sectors, where its unique electronic properties are exploited.

When handling 6-Methyl-1H-pyrrolo[3,2-c]pyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area away from heat sources and incompatible materials. In case of a spill, it should be carefully cleaned up using appropriate absorbents. Lab workers should consult the safety data sheet (SDS) for detailed handling instructions and emergency procedures.