Cetrorelix Acetate(CAS: 130143-01-0)

Cetrorelix Acetate is a white to off-white crystalline powder. Its molecular formula is C25H32N2O5 and molecular weight is 444.54 g/mol. It has low water solubility but is soluble in organic solvents like methanol and ethanol. Chemically, it is highly reactive with bases and can undergo hydrolysis under basic conditions.

Cetrorelix Acetate is synthesized through a multi-step process involving peptide synthesis and acetylation. Key steps include solid-phase peptide synthesis, coupling of the amino acids, and final acetylation. Commonly used catalysts include HBTU and HOAt, and the overall yield is approximately 70-80%.

Cetrorelix Acetate is primarily used in the pharmaceutical industry. It is an agonist of the gonadotropin-releasing hormone (GnRH) receptor and is used in fertility treatments, in particular for ovarian stimulation in assisted reproductive technologies. It is also used in the treatment of prostate cancer.

When handling Cetrorelix Acetate, standard personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn. It should be handled in a well-ventilated area or fume hood. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and the area should be rinsed with water. Safety data sheets (SDS) should be consulted for detailed handling and disposal information.