4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline(CAS: 288383-20-0)

This compound is a quinazoline derivative with a molecular weight of approximately 554.57 g/mol. It exhibits good solubility in common organic solvents such as DMSO, ethanol, and acetone. Chemically, it is stable under normal conditions but can react with strong acids or bases. It crystallizes in the form of a white or off-white solid.

This compound is synthesized through a multi-step process involving the coupling of 5-fluoro-2-methyl-1H-indole and 6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)quinazoline-4-carbaldehyde. The reaction is catalyzed by palladium(II) acetate and tri-tert-butylphosphine, yielding a high selectivity and good overall yield.

This compound has been utilized in the pharmaceutical industry for its potential anti-inflammatory and analgesic properties. It is also of interest in the development of new drug candidates for various diseases. Additionally, it may find applications in the polymer industry for its structural complexity and potential as a functional monomer.

When handling this compound, ensure proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood to avoid inhalation of vapors. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of a spill, immediate action should be taken according to the Safety Data Sheet (SDS) guidelines.