Pyrrole-3-carboxylic acid(CAS: 931-03-3)

Pyrrole-3-carboxylic acid is a white crystalline solid with a molecular weight of approximately 130.11 g/mol. It is sparingly soluble in water and more soluble in organic solvents. The compound is mildly acidic and reacts with bases to form salts. It is also known for its low volatility and stability under normal conditions.

Pyrrole-3-carboxylic acid is often synthesized via the condensation of pyrrole-3-carbonyl chloride with an amine, followed by hydrolysis. Another method involves the reaction of 3-formylpyrrole with a weak base, which can be catalyzed by a suitable acid or base. The yield and selectivity of these reactions depend on the specific reagents and conditions used.

Pyrrole-3-carboxylic acid finds applications in pharmaceuticals, where it serves as a precursor for drug synthesis. It is also utilized in the production of polymers and as a building block in the synthesis of various organic compounds. Additionally, it plays a role in the manufacture of sensors and semiconductors.

When handling Pyrrole-3-carboxylic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood to avoid inhalation of dust. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed safety information.