4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline(CAS: 214360-73-3)

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS: 214360-73-3) is a white crystalline powder. It has a molecular weight of approximately 330.4 g/mol. This compound is slightly soluble in water but freely soluble in organic solvents like ethanol and acetone. It is reactive towards electrophiles and can participate in Suzuki coupling reactions.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS: 214360-73-3) is synthesized by the boronic ester method, typically involving the reaction of an aryl halide or tosylate with a boronic acid in the presence of a base like sodium carbonate or potassium carbonate, and a palladium catalyst such as Pd(PPh3)2. The yield is usually high, around 80-90%.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS: 214360-73-3) is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry for the production of advanced materials and in the sensor and semiconductor industries for specialized applications.

When handling 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS: 214360-73-3), ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate methods and materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.