1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride (1:1)(CAS: 256499-19-1)

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride is a crystalline compound with a molecular weight of approximately 364.25 g/mol. It is slightly soluble in water and other polar solvents. The compound shows moderate reactivity under basic conditions and is stable under acidic conditions. It has a pKa of approximately 4.5.

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride is typically synthesized through multistep reactions involving the condensation of 2-fluorobenzylamine with 1H-pyrazolo[3,4-b]pyridine-3-carboximidamide using a Lewis acid catalyst. The yield is around 70-75%, and the reaction is carried out at room temperature.

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride is used in the pharmaceutical industry for its potential as a drug candidate. It may also find applications in the development of sensors, due to its chemical reactivity and stability under various conditions.

When handling 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride, safety glasses and gloves are recommended. Work should be conducted in a fume hood to avoid inhalation. Spills should be managed carefully using appropriate personal protective equipment (PPE) and cleaned up according to the Material Safety Data Sheet (SDS).