Methyl 3-hydroxy-1H-pyrrole-2-carboxylate(CAS: 79068-31-8)

Methyl 3-hydroxy-1H-pyrrole-2-carboxylate (CAS: 79068-31-8) is a crystalline solid with a molecular weight of approximately 154.17 g/mol. It is slightly soluble in water and has a pKa of about 4.5. This compound exhibits basic reactivity, making it susceptible to protonation. It is less reactive towards nucleophiles compared to the carboxylic acid form.

Methyl 3-hydroxy-1H-pyrrole-2-carboxylate (CAS: 79068-31-8) can be synthesized through a condensation reaction of methyl acetoacetate with pyrrole in the presence of a mild base. The reaction is typically performed at room temperature, and the yield can be up to 85% with high selectivity.

Methyl 3-hydroxy-1H-pyrrole-2-carboxylate (CAS: 79068-31-8) is used in the pharmaceutical industry for the synthesis of certain drug candidates due to its functional groups that can participate in further derivatization. It is also utilized in the polymer industry for the preparation of functional monomers and in the chemical sensor industry for sensor development.

When handling Methyl 3-hydroxy-1H-pyrrole-2-carboxylate (CAS: 79068-31-8), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be stored in a fume hood to minimize inhalation risk. In case of a spill, it should be contained and disposed of according to the Material Safety Data Sheet (MSDS) guidelines.