Hexyl salicylate(CAS: 6259-76-3)

Hexyl salicylate (CAS: 6259-76-3) is a colorless to pale yellow liquid with a molecular weight of 198.23 g/mol. It has a pKa of 3.0 and is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is less reactive, showing minimal reactivity with common reagents.

Hexyl salicylate is typically synthesized through the esterification of salicylic acid with hexanol in the presence of a strong acid catalyst like sulfuric acid. The process involves refluxing the mixture and then neutralizing the acid with a base to precipitate the product. The yield is generally around 85-90%, with good selectivity towards the desired ester.

Hexyl salicylate is widely used in the fragrance and flavor industry as a component of perfumes and colognes. It is also utilized in the pharmaceutical industry for its anti-inflammatory properties. Additionally, it finds applications in the polymer industry as a plasticizer and in the formulation of some pharmaceutical and cosmetic products.

When handling hexyl salicylate (CAS: 6259-76-3), it is important to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight and heat sources. Use a fume hood when handling the compound to avoid inhaling vapors. In case of a spill, immediately clean up the area, ensuring proper disposal of waste. Refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.