N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide(CAS: 120287-85-6)

N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide is a crystalline compound with a high molecular weight. It has a high solubility in polar solvents such as dimethyl sulfoxide (DMSO) and low solubility in non-polar solvents. The compound is known for its reactivity, particularly in peptide bond formation and cleavage. It is also stable in acidic and basic conditions.

N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide is typically synthesized via solid-phase peptide synthesis (SPPS) methods. The synthesis involves the sequential addition of amino acid derivatives to a growing peptide chain using a suitable coupling agent and activation method. Commonly used coupling agents include HATU and DIC, with the coupling process being highly selective and yielding up to 95% purity.

N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide is primarily used in the pharmaceutical industry for the development of novel peptide-based therapeutics. It is also relevant in the polymer industry for the synthesis of functionalized peptides and in the field of sensors for its unique chemical reactivity.

When handling N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N~5~-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always consult the safety data sheet (SDS) for detailed handling and disposal procedures.