2,3-Dihydro-1-benzofuran-5-carboxylic acid(CAS: 76429-73-7)

2,3-Dihydro-1-benzofuran-5-carboxylic acid is a solid at room temperature with a molecular weight of approximately 184.21 g/mol. It has a melting point of 180-182°C and is soluble in organic solvents like ethanol and acetone but less so in water. It is a weak acid and can undergo typical carboxylic acid reactions such as esterification and acid-base reactions.

2,3-Dihydro-1-benzofuran-5-carboxylic acid can be synthesized by the ring-opening of 1,2-dihydrobenzofuran with a carboxylation reagent. Common methods include the reaction of 1,2-dihydrobenzofuran with carbon dioxide in the presence of a base such as potassium carbonate. This process typically yields a pure product with high selectivity and good yield.

2,3-Dihydro-1-benzofuran-5-carboxylic acid finds applications in the pharmaceutical industry as an intermediate for drug synthesis, in the polymer industry for the production of certain resins, and in the sensor industry for the development of chemical sensors. It is also used in semiconductor manufacturing for specific purification processes.

When handling 2,3-Dihydro-1-benzofuran-5-carboxylic acid, appropriate personal protective equipment (PPE) such as safety goggles, gloves, and lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation of any vapors. Spills should be immediately cleaned up with appropriate absorbents and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.