4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide(CAS: 301836-41-9)

4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide is a crystalline solid with a molecular weight of approximately 414.28 g/mol. It has a low solubility in water but is soluble in organic solvents such as dichloromethane and ethanol. This compound exhibits moderate reactivity towards nucleophiles and is stable under neutral and acidic conditions. Its properties make it suitable for use in medicinal chemistry and drug development.

4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide is synthesized through multi-step reactions involving the coupling of 2-pyridinecarboxaldehyde, 1,3-benzenedicarbonitrile, and 2-aminobenzamide. The process involves the formation of an imidazole ring, followed by the introduction of the 1,3-benzo[d]oxole and pyridinyl substituents. The reaction is catalyzed by a palladium complex and typically yields pure products with high selectivity and good yield.

4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide is primarily used in the pharmaceutical industry for the development of antiviral and anti-inflammatory drugs. It is also of interest in the sensor and semiconductor industries due to its unique chemical properties. Its application in these industries highlights its potential for various scientific and technological advancements.

When handling 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure that the substance is handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up immediately using appropriate procedures, and all waste should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.