Anastrozole EP Impurity C(CAS: 120511-84-4)

Anastrozole EP Impurity C (CAS: 120511-84-4) is a white to off-white crystalline compound with a molecular weight of approximately 308.34 g/mol. It has a melting point of about 150-155°C and is slightly soluble in water. It is unstable under basic conditions and shows some reactivity with strong oxidizing agents. This impurity is often characterized by its specific UV absorption and chromatographic behavior.

Anastrozole EP Impurity C (CAS: 120511-84-4) is synthesized through a series of chemical reactions starting from benzene derivatives. The process involves a Friedel-Crafts alkylation, followed by oxidation and hydrolysis steps. The reaction conditions typically require the use of Lewis acids and strong oxidizing agents. The synthesis yields a mixture of products, including the desired impurity, with selectivity and yield varying depending on the specific reaction conditions.

Anastrozole EP Impurity C (CAS: 120511-84-4) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of anastrozole, a breast cancer treatment. It is also of interest in analytical chemistry for quality control and impurity profiling of anastrozole products.

Handling Anastrozole EP Impurity C (CAS: 120511-84-4) requires the use of personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up using appropriate absorbent materials, followed by thorough rinsing with water. For detailed safety information, refer to the Safety Data Sheet (SDS) provided by the manufacturer.