Ethyl 2-chloro-1,3-oxazole-5-carboxylate(CAS: 862599-47-1)

Ethyl 2-chloro-1,3-oxazole-5-carboxylate is a white crystalline solid with a molecular weight of approximately 197.03 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored away from moisture and strong acids.

Ethyl 2-chloro-1,3-oxazole-5-carboxylate can be synthesized via the reaction of 2-chloro-1,3-oxazole-5-carboxylic acid with ethyl chloromethyl ketone. This process typically involves the use of a base like sodium hydroxide and is conducted under reflux conditions. The yield is generally good, and the product is isolated by recrystallization from ethanol.

Ethyl 2-chloro-1,3-oxazole-5-carboxylate is used in the pharmaceutical industry for the synthesis of various pharmaceuticals, particularly in medicinal chemistry. It is also utilized in the polymer industry for the development of novel materials and in the field of sensors for its unique chemical properties.

When handling Ethyl 2-chloro-1,3-oxazole-5-carboxylate, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be used in a fume hood due to its potential for vapor release. In case of a spill, it should be cleaned up using an appropriate absorbent material, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal information.