1-Bromo-2-(trifluoromethoxy)benzene(CAS: 64115-88-4)

1-Bromo-2-(trifluoromethoxy)benzene (CAS: 64115-88-4) is a crystalline solid with a molecular weight of approximately 269.03 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetone. It is a moderately reactive compound, particularly with nucleophiles. It is a dense, non-volatile liquid at room temperature.

1-Bromo-2-(trifluoromethoxy)benzene can be synthesized by the Friedel-Crafts alkylation of 2-(trifluoromethoxy)benzene with bromine in the presence of aluminum trichloride as a catalyst. The reaction yields a mixture of 1-bromo-2-(trifluoromethoxy)benzene and 2-bromo-1-(trifluoromethoxy)benzene. The reaction is typically conducted under anhydrous conditions to prevent side reactions.

1-Bromo-2-(trifluoromethoxy)benzene is used in the pharmaceutical industry for the synthesis of drug intermediates. It is also used in the electronics industry as a precursor in the production of organic semiconductors and in the polymer industry for the synthesis of fluorinated polymers. The compound's unique chemical properties make it valuable in these applications.

When handling 1-Bromo-2-(trifluoromethoxy)benzene (CAS: 64115-88-4), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents and the area should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.