1-Methyl-1,2,3,6-tetrahydropyridine hydrochloride (1:1)(CAS: 73107-26-3)

1-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is a white crystalline solid with a molecular weight of approximately 227.66 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol. The compound is moderately reactive, showing good stability under normal conditions but can degrade under acidic or basic conditions. It has a pKa of about 1.5 and is used as a proton donor in various chemical reactions.

1-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is typically synthesized by the reaction of 1-methyl-1,2,3,6-tetrahydropyridine with hydrochloric acid. The synthesis involves the protonation of the nitrogen atom in the pyridine ring. Commonly, the reaction is carried out in a solvent such as ethanol or acetic acid, and the yield is usually around 85-90%. This process is catalyzed by the acid, and the product can be isolated by recrystallization.

1-Methyl-1,2,3,6-tetrahydropyridine hydrochloride is used in various industries, primarily in pharmaceuticals and research. It acts as a precursor in the synthesis of other compounds and is also used in the formulation of certain drugs. Additionally, it has applications in the production of sensors and as a reagent in semiconductor manufacturing processes.

When handling 1-Methyl-1,2,3,6-tetrahydropyridine hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Ensure that the work is conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be handled by sweeping up the solid material and disposing of it according to waste management guidelines. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.