2-Fluoro-5-methylbenzoic acid(CAS: 321-12-0)

2-Fluoro-5-methylbenzoic acid (CAS: 321-12-0) is a white solid with a molecular weight of approximately 160.04 g/mol. It has a melting point of 128-129°C and is slightly soluble in water. Chemically, it shows typical reactivity for carboxylic acids, including esterification and acylation reactions. It is also prone to electrophilic aromatic substitution reactions.

2-Fluoro-5-methylbenzoic acid is commonly synthesized through the bromination of 5-methylbenzoic acid followed by the removal of the bromine atom in the presence of a suitable reducing agent like sodium sulfide. Other methods involve the direct fluorination of 5-methylbenzoic acid using fluorine gas under controlled conditions.

2-Fluoro-5-methylbenzoic acid (CAS: 321-12-0) is used in the pharmaceutical industry for the synthesis of certain drugs, as a precursor in polymer synthesis, and in the production of sensors and semiconductors due to its unique chemical properties.

When handling 2-Fluoro-5-methylbenzoic acid (CAS: 321-12-0), it is important to wear personal protective equipment (PPE) including gloves and safety goggles. The substance should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate waste disposal procedures, and the Safety Data Sheet (SDS) should be consulted for specific handling instructions.