1-Isocyanato-4-(trifluoromethyl)benzene(CAS: 1548-13-6)

1-Isocyanato-4-(trifluoromethyl)benzene (CAS: 1548-13-6) is a solid with a crystalline form. Its molecular weight is approximately 224.09 g/mol. It has low solubility in water but is soluble in organic solvents like dichloromethane and acetone. It is mildly reactive, particularly with primary amines to form isocyanurates. It is a colorless solid with a melting point of 50-52°C.

1-Isocyanato-4-(trifluoromethyl)benzene (CAS: 1548-13-6) is typically synthesized by reacting trifluoromethylbenzoyl chloride with ammonia in the presence of a catalyst such as dimethylformamide (DMF) and potassium carbonate. The process involves a nucleophilic substitution reaction, yielding a high yield with good selectivity.

1-Isocyanato-4-(trifluoromethyl)benzene (CAS: 1548-13-6) is used in the pharmaceutical industry for the synthesis of certain compounds and in the polymer industry as a monomer. It also finds applications in the development of sensors and semiconductors.

When handling 1-Isocyanato-4-(trifluoromethyl)benzene (CAS: 1548-13-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood. Proper storage in a cool, dry place away from heat sources is recommended. In case of spill, immediately clean up the area and refer to the Material Safety Data Sheet (MSDS) for further guidance.