Ethyl 1-methyl-3-piperidinecarboxylate(CAS: 5166-67-6)

Ethyl 1-methyl-3-piperidinecarboxylate (CAS: 5166-67-6) is a colorless to slightly yellow liquid with a molecular weight of 152.22 g/mol. It has a melting point of -6.0°C and a boiling point of 224-225°C. This compound is soluble in water and ethanol. It is moderately reactive, particularly towards nucleophilic attack and acidic hydrolysis.

Ethyl 1-methyl-3-piperidinecarboxylate (CAS: 5166-67-6) is synthesized via the reaction of 1-methyl-3-piperidinecarboxylic acid with ethyl chloroformate in the presence of a base, such as diisopropylethylamine. The reaction is typically carried out at room temperature with high yield and good purity.

Ethyl 1-methyl-3-piperidinecarboxylate (CAS: 5166-67-6) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of drugs. It is also utilized in the synthesis of certain polymers and as a precursor in organic synthesis.

Ethyl 1-methyl-3-piperidinecarboxylate (CAS: 5166-67-6) should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Keep away from heat, sparks, and flames. Store in a cool, dry place and avoid contact with water. In case of a spill, use appropriate spill cleanup procedures and refer to the Safety Data Sheet (SDS) for further guidelines.