(3S)-3-Aminobutanoic acid(CAS: 3775-72-2)

(3S)-3-Aminobutanoic acid, also known as (S)-aminovaleric acid, is a colorless crystalline solid with a molecular weight of approximately 111.13 g/mol. It has a bitter taste and a pKa of 2.16. The compound is slightly soluble in water (1.3 g/100 mL at 25°C) and practically insoluble in ethanol. It is a chiral compound and reacts with carboxylic acids to form amides. It is also susceptible to hydrolysis under basic conditions.

(3S)-3-Aminobutanoic acid can be synthesized through the reduction of (S)-3-oxobutanoic acid using sodium borohydride or other reducing agents. Another method involves the condensation of (S)-3-bromopropionic acid with ammonia or methylamine. These methods provide good yields and can be optimized for industrial-scale production. The use of chiral catalysts can enhance the enantioselectivity in these reactions.

(3S)-3-Aminobutanoic acid finds applications in various industries. In pharmaceuticals, it serves as a building block for the synthesis of biologically active molecules. In polymer science, it is used as a monomer for the production of biodegradable polymers. Additionally, it is employed in the development of sensors and semiconductors due to its chiral nature and specific chemical properties.

When handling (3S)-3-Aminobutanoic acid, it is important to use appropriate personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, avoid inhalation and use appropriate spill kits or absorbents. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines and emergency procedures. Storage should be in a cool, dry place away from incompatible materials and heat sources.