N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyltyrosine(CAS: 77128-72-4)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyltyrosine is a white crystalline solid with a molecular weight of approximately 414.4 g/mol. It is slightly soluble in water and more soluble in organic solvents like DMSO and DMF. This compound is reactive towards nucleophiles and can undergo esterification and other organic reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyltyrosine is synthesized via multi-step reactions including acylation, methylation, and coupling with fluorenylmethanol. Common reagents include carbodiimides and hydroxybenzotriazoles as coupling agents, with yields varying between 70-90%. The synthesis is typically performed in polar aprotic solvents under anhydrous conditions.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyltyrosine is used in pharmaceuticals for drug synthesis and modification. It is also employed in the development of sensors and semiconductors, particularly in the field of organic electronics. Its unique chemical structure makes it valuable in polymer chemistry for the synthesis of advanced materials.

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyltyrosine, wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In case of spillage, refer to the Safety Data Sheet (SDS) for appropriate cleanup procedures.