1,3-Benzoxazole-6-carbaldehyde(CAS: 865449-97-4)

1,3-Benzoxazole-6-carbaldehyde is a crystalline solid with a molecular weight of approximately 182.17 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetone. Chemically, it is relatively stable but can undergo condensation reactions with amines and other nucleophiles. Its vapor pressure is very low, and it is slightly reactive under basic conditions.

1,3-Benzoxazole-6-carbaldehyde is often synthesized via the condensation of benzaldehyde and oxazole, or by the alkylation of 1,3-benzoxazine-6-carbonitrile. The reaction typically involves the use of a base like sodium hydroxide to promote deprotonation and subsequent nucleophilic substitution. The yield is generally good, and the product can be purified by recrystallization.

1,3-Benzoxazole-6-carbaldehyde finds applications in the pharmaceutical industry for the synthesis of bioactive compounds and in the production of polymers with enhanced thermal stability. It is also used in the development of sensors due to its characteristic chemical reactivity and in semiconductor technology for its electronic properties.

When handling 1,3-Benzoxazole-6-carbaldehyde, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation risks. Spills should be cleaned up using appropriate absorbents, and proper waste disposal procedures should be followed. Always refer to a safety data sheet (SDS) for detailed handling instructions and emergency procedures.