4-(3-Formylphenoxy)benzonitrile(CAS: 90178-72-6)

4-(3-Formylphenoxy)benzonitrile is a white crystalline solid with a molecular weight of 234.19 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. The compound is known for its limited reactivity under normal conditions, but it can undergo condensation and electrophilic aromatic substitution reactions. It is insoluble in acetic acid and slightly soluble in benzene.

4-(3-Formylphenoxy)benzonitrile is typically synthesized via the reaction of 4-bromobenzonitrile with 3-formylphenol in the presence of a base such as potassium carbonate. The reaction is carried out in an inert solvent like dimethylformamide (DMF) at elevated temperatures to ensure high yield and selectivity. The product undergoes a condensation reaction forming the desired product with good yield.

4-(3-Formylphenoxy)benzonitrile is used in the pharmaceutical industry for the synthesis of certain drugs due to its functional groups that can participate in further modifications. It also has potential applications in the polymer industry for the development of new materials with specific properties. Additionally, it may be used in the production of sensors and semiconductors as a precursor or intermediate.

Handling 4-(3-Formylphenoxy)benzonitrile requires appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.