6-(5-Chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one(CAS: 43200-81-3)

6-(5-Chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one is a crystalline solid with a molecular weight of approximately 294.03 g/mol. Its solubility in water is low, around 2 mg/L. It is relatively stable but can react with strong acids and bases. It has a pKa of around 5.5, indicating it can act as a weak acid.

6-(5-Chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one is typically synthesized via a multistep process involving the reaction of 2-chloropyridine with 7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one. Suitable catalysts are used to enhance reactivity and selectivity, with overall yields of about 75%.

6-(5-Chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one is used in the pharmaceutical industry for the development of anti-inflammatory and anti-allergic drugs. It also finds applications in the synthesis of other heterocyclic compounds for various chemical and biological studies.

When handling 6-(5-Chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be handled using appropriate safety measures and materials as outlined in the safety data sheet (SDS).