2-Chloro-5-nitro-4-pyridinamine(CAS: 2604-39-9)

2-Chloro-5-nitro-4-pyridinamine is a crystalline solid with a molecular weight of approximately 225.6 g/mol. It is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. The compound is known for its reactivity, particularly towards nucleophilic substitution and reduction reactions.

2-Chloro-5-nitro-4-pyridinamine can be synthesized via the nitration of 2-chloro-4-pyridinamine followed by purification. Commonly, this involves treating 2-chloro-4-pyridinamine with nitric acid and sulfuric acid in a solvent like acetic acid. The product is then isolated and purified using recrystallization.

2-Chloro-5-nitro-4-pyridinamine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the sensor industry for the development of chemical sensors, and in the research of new materials for their potential use in semiconductor technology.

When handling 2-Chloro-5-nitro-4-pyridinamine, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be handled in a fume hood due to its potential volatility and reactivity. Spills should be cleaned up with caution using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.