1-(2-Hydroxyethyl)-2-pyrrolidinone(CAS: 3445-11-2)

1-(2-Hydroxyethyl)-2-pyrrolidinone (CAS: 3445-11-2) is a colorless or light yellow, viscous liquid with a molecular weight of approximately 123.17 g/mol. It has a high solubility in water and organic solvents. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It is slightly hygroscopic and exhibits good miscibility with water and ethanol.

1-(2-Hydroxyethyl)-2-pyrrolidinone (CAS: 3445-11-2) is typically synthesized via the Mannich reaction between pyrrolidine, formaldehyde, and hydroxylamine hydrochloride. Common catalysts include boron trifluoride etherate or trifluoroacetic acid. The yield can reach up to 90%, and the reaction is carried out in an ethanol or methanol solvent at room temperature.

1-(2-Hydroxyethyl)-2-pyrrolidinone (CAS: 3445-11-2) is widely used in pharmaceuticals for solubilizing poorly water-soluble drugs, in polymers as an ingredient for improving properties, in sensors as a solvent, and in semiconductors for etching and cleaning processes. It is also used in personal care products for its moisturizing properties.

When handling 1-(2-Hydroxyethyl)-2-pyrrolidinone (CAS: 3445-11-2), it is important to use personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.