[4-(Benzyloxy)-3-fluorophenyl]boronic acid(CAS: 133057-83-7)

[4-(Benzyloxy)-3-fluorophenyl]boronic acid is a white or off-white crystalline solid with a molecular weight of approximately 299.22 g/mol. It has a solubility in water of less than 1 g/L at 25°C. This compound is reactive towards acidic conditions and can undergo various chemical transformations, including coupling reactions and esterification.

[4-(Benzyloxy)-3-fluorophenyl]boronic acid is usually synthesized by the reaction of 3-fluorobenzoic acid with phenyl boronic acid in the presence of a base such as sodium carbonate, using a suitable solvent like methanol or ethanol. The reaction typically occurs at elevated temperatures and yields up to 90% of the product, with good selectivity towards the boronic ester.

[4-(Benzyloxy)-3-fluorophenyl]boronic acid finds applications in the pharmaceutical industry as a precursor in the synthesis of complex molecules and in organic synthesis. It is also utilized in the polymer industry for the preparation of functional polymers and in the development of sensing materials for various applications.

When handling [4-(Benzyloxy)-3-fluorophenyl]boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be thoroughly cleaned up using appropriate chemical spill kits, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.