2-Methyl-4-pyrimidinecarboxylic acid(CAS: 13627-49-1)

2-Methyl-4-pyrimidinecarboxylic acid is a white crystalline solid with a molecular weight of approximately 165.15 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive towards bases and can undergo condensation reactions. It has a pKa of about 6.1 and is used in various applications due to its acidic nature.

2-Methyl-4-pyrimidinecarboxylic acid is typically synthesized by the reaction of 2-hydrazinomethylpyrimidine with acetic anhydride in the presence of a catalyst like p-toluenesulfonic acid. The reaction is carried out at room temperature, and the product is isolated by recrystallization from water. This method provides a yield of about 75%.

2-Methyl-4-pyrimidinecarboxylic acid is used in the pharmaceutical and agrochemical industries for the synthesis of various drugs and pesticides. It is also applied in the polymer industry for the production of advanced polymers with specific chemical properties. Additionally, it is used in the electronics industry for the development of semiconductor materials and sensors.

When handling 2-Methyl-4-pyrimidinecarboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.