4-(4-Bromophenyl)piperidine(CAS: 80980-89-8)

4-(4-Bromophenyl)piperidine (CAS: 80980-89-8) is a crystalline solid with a molecular weight of approximately 248.03 g/mol. It has limited water solubility and is soluble in organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but can degrade upon prolonged exposure to heat or light.

4-(4-Bromophenyl)piperidine (CAS: 80980-89-8) is synthesized via a multistep process involving bromination and subsequent piperidine coupling. The bromination step typically uses N-bromosuccinimide (NBS) in the presence of a radical initiator like dibenzoyl peroxide. The coupling is facilitated by a suitable amine base in an aprotic solvent like acetonitrile, with a high yield of up to 90%.

4-(4-Bromophenyl)piperidine (CAS: 80980-89-8) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various piperidine-based drugs. It also finds applications in polymer synthesis for the development of advanced materials and in the production of chemical sensors for detecting specific compounds.

When handling 4-(4-Bromophenyl)piperidine (CAS: 80980-89-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with caution, using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed handling and disposal instructions.