3-(3-Fluorophenyl)propanoic acid(CAS: 458-45-7)

3-(3-Fluorophenyl)propanoic acid is a white crystalline solid with a molecular weight of approximately 188.18 g/mol. It has a melting point of 88-89°C and is slightly soluble in water. Chemically, it is relatively stable but can undergo esterification and amide formation. It is used as a precursor in various organic syntheses.

3-(3-Fluorophenyl)propanoic acid is typically synthesized via a multistep process involving the reaction of 3-fluorophenyl methyl ether with acrylonitrile followed by hydrolysis. The synthesis involves the use of acetic anhydride and sodium hydroxide, with high selectivity and yield.

3-(3-Fluorophenyl)propanoic acid is used in the pharmaceutical industry as an intermediate for drug synthesis. It is also utilized in the production of certain polymers and as a component in sensors and semiconductors due to its unique chemical properties.

When handling 3-(3-Fluorophenyl)propanoic acid, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a laboratory coat. It should be stored in a cool, dry place away from direct sunlight. In case of spill, it should be handled with care, and proper containment and disposal procedures should be followed, as per the Material Safety Data Sheet (MSDS).