2-Chloro-3-methylisonicotinic acid(CAS: 133928-73-1)

2-Chloro-3-methylisonicotinic acid is a crystalline solid at room temperature with a molecular weight of approximately 186.62 g/mol. It is slightly soluble in water and has a pKa of about 2.4. The compound is moderately reactive, particularly towards nucleophiles, and can undergo substitution reactions easily.

2-Chloro-3-methylisonicotinic acid is usually synthesized via the electrophilic substitution of 3-methylisonicotinic acid with chlorine. A common method involves reacting 3-methylisonicotinic acid with thionyl chloride in pyridine. The reaction is conducted at elevated temperatures to achieve good yields and good selectivity.

2-Chloro-3-methylisonicotinic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for modifying properties of polymers and in sensor technology for developing chemical sensors. Additionally, it is utilized in the semiconductor industry for doping processes.

When handling 2-Chloro-3-methylisonicotinic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate materials, and the area should be thoroughly washed. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information.