2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS: 68716-49-4)

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS: 68716-49-4) is a colorless to white crystalline solid with a molecular weight of approximately 331.05 g/mol. It is moderately soluble in water but has good solubility in organic solvents such as methanol, ethanol, and acetonitrile. The compound exhibits good reactivity towards boron-containing reagents and is often used in cross-coupling reactions. It is stable under normal laboratory conditions but should be protected from moisture and oxygen.

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS: 68716-49-4) is typically synthesized via a bromination reaction of 2,4,4,5,5-pentamethyl-1,3,2-dioxaborolane with 4-bromoaniline in the presence of a base like sodium hydroxide. The reaction is carried out under mild conditions and yields a high purity product with good selectivity and yield. The reaction is monitored by GC or NMR spectroscopy to ensure complete conversion.

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS: 68716-49-4) is widely used in the pharmaceutical and polymer industries for its reactivity in cross-coupling reactions. It is also employed in the development of sensors and semiconductor materials due to its unique chemical properties. The compound's ability to participate in boron-catalyzed reactions makes it valuable in organic synthesis and materials science.

When handling 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS: 68716-49-4), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a fume hood under an inert atmosphere to prevent oxidation. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and the area should be properly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.