(±)-Norcantharidin(CAS: 29745-04-8)

(±)-Norcantharidin is a crystalline compound with a molecular weight of approximately 258.22 g/mol. It has a melting point of 220-223°C and is poorly soluble in water, but soluble in organic solvents such as ethanol and acetone. It is moderately reactive towards bases and light, making it sensitive to degradation under these conditions.

(±)-Norcantharidin can be synthesized via a multi-step organic synthesis route, starting from 1,4-naphthoquinone. Common synthetic methods include vicinal diol introduction and subsequent ring closure. The reaction typically requires the use of Lewis acids as catalysts and achieves a yield of around 60-70%.

(±)-Norcantharidin finds applications in the pharmaceutical industry, particularly in the development of antineoplastic agents. It is also used in research for its photochemical and photophysical properties, making it relevant to studies in polymer science and semiconductor technology.

When handling (±)-Norcantharidin, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation. Spills should be cleaned up using appropriate materials, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.