3-(Methylsulfanyl)propanoyl chloride(CAS: 7031-23-4)

3-(Methylsulfanyl)propanoyl chloride is a colorless to white crystalline solid with a molecular weight of approximately 158.17 g/mol. It has a melting point of 64-66°C and is soluble in organic solvents such as dichloromethane and methanol. It is moderately reactive, especially towards nucleophiles and bases, making it useful in various synthetic applications.

3-(Methylsulfanyl)propanoyl chloride is typically synthesized by the chlorination of 3-(methylthio)propanoic acid. This is usually achieved using thionyl chloride in a non-nucleophilic solvent like toluene at room temperature. The reaction is known for its high yield and good selectivity.

3-(Methylsulfanyl)propanoyl chloride finds applications in pharmaceuticals, where it serves as an intermediate for drug synthesis. It is also used in the production of certain polymers and as a reagent in analytical chemistry, particularly in the development of sensors and semiconductors.

When handling 3-(Methylsulfanyl)propanoyl chloride, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a sealed container and handled in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, immediately clean up using appropriate absorbent materials and consult the Safety Data Sheet (SDS) for further guidance.