Benzyl (2R)-2-cyano-1-pyrrolidinecarboxylate(CAS: 620601-77-6)

Benzyl (2R)-2-cyano-1-pyrrolidinecarboxylate (CAS: 620601-77-6) is a crystalline solid with a molecular weight of approximately 257.25 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound is known for its reactivity, particularly towards nucleophilic substitution reactions. It has a pKa of about 3, indicating some basicity.

Benzyl (2R)-2-cyano-1-pyrrolidinecarboxylate is typically synthesized via the reaction of benzyl bromide with (2S)-2-cyano-1-pyrrolidinecarboxylic acid under the presence of a base like sodium hydride. The reaction involves nucleophilic substitution and leads to a high yield. The product is then purified by recrystallization from ethanol.

Benzyl (2R)-2-cyano-1-pyrrolidinecarboxylate (CAS: 620601-77-6) is primarily used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry for the modification of polymer properties and in sensor technology for analytical purposes.

When handling Benzyl (2R)-2-cyano-1-pyrrolidinecarboxylate (CAS: 620601-77-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a fume hood due to its volatility. Spills should be cleaned up immediately using absorbent materials, and the area should be well-ventilated. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS).