3-(4-Fluorophenyl)-1H-indole(CAS: 101125-32-0)

3-(4-Fluorophenyl)-1H-indole is a crystalline solid with a molecular weight of approximately 209.18 g/mol. It has a low solubility in water but is moderately soluble in organic solvents like ethanol and dimethylformamide. Chemically, it is relatively stable but can undergo electrophilic aromatic substitution reactions under certain conditions.

3-(4-Fluorophenyl)-1H-indole can be synthesized via a multistep process involving a Stille coupling reaction between 4-fluorophenylboronic acid and indole-3-boronic acid. The reaction is catalyzed by palladium(0) and typically yields high purity products with excellent selectivity and moderate to high yields.

3-(4-Fluorophenyl)-1H-indole is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drug candidates. It also has applications in the development of sensors and in materials science for its unique optical and electronic properties.

When handling 3-(4-Fluorophenyl)-1H-indole, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a laboratory coat. Work should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate materials, and the material safety data sheet (MSDS) should be consulted for detailed safety information.