(2,5-Difluorophenyl)boronic acid(CAS: 193353-34-3)

(2,5-Difluorophenyl)boronic acid is a white or off-white crystalline solid with a molecular weight of approximately 215.08 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol and acetonitrile. This compound is used as a building block in organic synthesis and displays specific reactivity towards boron-containing compounds, making it suitable for various reactions.

(2,5-Difluorophenyl)boronic acid can be synthesized via a variety of methods. Commonly, it is produced by reacting 2,5-difluorophenol with boron tribromide followed by treatment with sodium borohydride. This synthesis provides good yield and selectivity, making it a reliable method for obtaining this compound in the laboratory and industrial settings.

(2,5-Difluorophenyl)boronic acid is utilized in several industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of pharmaceuticals; polymers, where it can be used as a monomer or additive; and in sensors and semiconductors, where its unique properties make it valuable for specific applications.

When handling (2,5-Difluorophenyl)boronic acid, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat to protect against skin and eye contact. Work should be conducted in a fume hood to minimize inhalation. Spills should be cleaned up carefully using appropriate procedures, and the material safety data sheet (MSDS) should be consulted for detailed guidelines on safe handling and disposal.